(10-11-09) The Diabetes?Cancer Connection

It?s American Diabetes Month, a time to highlight the many ways people can prevent and control this disease and its
health complications. Diabetes increases people?s risk for several conditions, including heart attacks. Now there may be another health risk to add: cancer.
Studies suggest that people with diabetes and signs of diabetes may also be at increased risk for certain cancers.

What?s Going On?

For most people, diabetes stems from problems with the production of insulin, a hormone made in the pancreas.

When someone no longer makes insulin it?s diagnosed as type 1
diabetes; when someone doesn?t make enough insulin or the body doesn?t use it normally, it?s type 2. Either way, it can result in high blood sugar levels and cells that aren?t getting the energy they need. In type 2 high blood sugar can also trigger the production of more insulin, leading to too much insulin in the blood.

According to the Centers for Disease Control and Prevention diabetes
now affects approximately 24 million American, nearly 8 percent of the U.S.
population. In addition to the 24 million with diabetes, another 57 million are estimated to have pre?diabetes, a condition that puts people at increased risk for diabetes. In pre?diabetes, a person?s blood glucose levels are higher than normal but not high enough to qualify for diabetes.
The Link

The connection between signs of insulin resistance and cancer is strongest among certain types of cancers, including colon and pancreatic.

For example, a 2006 study published in the Journal of the National Cancer Institute found that men who had signs of the highest insulin levels were almost three times more likely to develop colon cancer than men with the lowest levels. Other studies found
increased risk in people with type 2 diabetes and prediabetes.

Many studies have shown a link between pancreatic cancer and diabetes. Yet because pancreatic cancer and diabetes both involve the pancreas, evidence remains unclear on whether diabetes causes or results from the cancer.

Although the association is not as strong, studies have also linked diabetes to prostate, endometrial, liver and breast cancers.

The Risk Factors

High amounts of insulin, type 2 diabetes and cancer all share a major risk factor: high body fat. AICR?s second expert report found that high body fat is convincingly linked to increased risk of several cancers, including pancreatic and colorectal.

Excess body fat can lead to the pancreas producing excess amounts
of insulin. And studies have shown that insulin stimulates cell proliferation and tumor growth.

Also, high levels of insulin, independent of body fat, are
linked to increased production of insulin?:like growth factor 1 (IGF-1), which plays a key role in promoting cancer cell growth.

Lowering the Risk

In the same way that similar factors increase risks for both cancer and diabetes, there are similar ways people can lower their risk. Maintaining a healthy weight and physical activity can decrease the risk of cancer and diabetes.

For cancer, Americans could prevent approximately 100,500 cases of cancer annually if they maintained low body fat. For diabetes, a major study sponsored by the National Institutes of Health found that people at increased risk for type 2 diabetes can significantly prevent or delay the onset of the disease by losing 5 to 7 percent of their body weight through increased physical activity and diet.

For More Information

For simple strategies and tips for healthy lifestyle habits:

AICR?s New American Plate
Moving More for Cancer Prevention

For specific information on diabetes:

Diabetes & Me, National Center for
Chronic Disease Prevention and Health Promotion
All About Diabetes, American
Diabetes Association


Source: http://www.aicr.org

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.