(13-01-10) Cellular mechanisms of cardioprotection by calorie restriction: state of the science and future perspectives.

Marzetti E, Wohlgemuth SE, Anton SD, Bernabei R, Carter CS, Leeuwenburgh C.
Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, 1600 SW Archer Road,Gainesville, FL 32610-0143, USA. [email protected]

Evidence from animal models and preliminary studies in humans indicates that calorie restriction (CR) delays cardiac aging and can prevent cardiovascular disease. These effects are mediated by a wide spectrum of biochemical and cellular adaptations, including redox homeostasis, mitochondrial function, inflammation, apoptosis, and autophagy. Despite the beneficial effects of CR, its large-scale implementation is challenged by applicability issues as well as health concerns. However, preclinical studies indicate that specific compounds, such as resveratrol, may mimic many of the effects of CR, thus potentially obviating the need for drastic food intake reductions. Results from ongoing clinical trials will reveal whether the intriguing alternative of CR mimetics represents a safe and effective strategy to promote cardiovascular health and delay cardiac aging in humans.

Source: Clin Geriatr Med. 2009 Nov;25(4):715-32, ix.

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