(15-01-10) Obesity, coffee consumption and CRP levels in postmenopausal overweight/obese women:

importance of hormone replacement therapy use



Contributions: CPE, SNB and TSC designed the study; BJA and TSC analyzed the data and wrote this paper; CPE, J-PD, SNB and TSC reviewed and edited this paper. All authors contributed to and approved the final version of this paper.
B J Arsenault1,2, C P Earnest3, J-P Despr?s1,4, S N Blair5,6 and T S Church3
1. 1Centre de recherche de l'Institut universitaire de Cardiologie et de pneumologie de Qu?bec, Department of Cardiology, Qu?bec, Canada
2. 2Department of Anatomy and Physiology, Faculty of Medicine, Universit? Laval, Qu?bec, Canada
3. 3Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
4. 4Division of Kinesiology, Department of Social and Preventive Medicine, Universit? Laval, Qu?bec, Canada
5. 5Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
6. 6Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA
Correspondence: Dr TS Church, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 708-08-4124, USA. E-mail: [email protected]
Received 21 December 2008; Revised 25 May 2009; Accepted 7 July 2009; Published online 16 September 2009.
Top of page
Abstract
Background/Objectives:

Obesity is associated with an inflammatory state that is often characterized by elevated plasma C-reactive protein (CRP) levels. Although coffee is broadly consumed in Western societies, few studies have examined the relationship between obesity, coffee consumption and CRP levels. The objective of this study was to assess the relationship between obesity, coffee consumption and variation in CRP in postmenopausal, overweight/obese women with or without hormone replacement therapy (HRT) use.
Subjects/Methods:

Cross-sectional analyses of 344 healthy sedentary, overweight/obese postmenopausal women (mean age=57.1 6.4 years and mean body mass index (BMI)=36.1 3.9 kg/ m2). Plasma CRP levels were measured by a highly sensitive immunoassay that used monoclonal antibodies coated with polystyrene particles. Diet was assessed using the Food Intake and Analysis System semiquantitative food frequency questionnaire.
Results:

Plasma CRP was positively associated with BMI (P<0.001) and negatively associated with coffee consumption (P 0.05). In women using HRT, plasma CRP was positively associated with BMI in women consuming less than one cup of coffee per month (r 2=0.15 (P<0.001)), one cup per day (0.14 (P=0.02)) and more than one cup per day (0.12 (P=0.03)). In women who did not use HRT, CRP was associated with BMI only in women consuming less than one cup of coffee per day (r 2=0.16 (P<0.001)) but not in women consuming one cup per day (0.06 (P=0.10)) or more than one daily cup of coffee (0.03 (P=0.27)).
Conclusions:

Among overweight/obese postmenopausal women, coffee consumption is negatively associated with CRP. Coffee consumption appears to attenuate the association between BMI and CRP, but only in women not using HRT
.
Source: European Journal of Clinical Nutrition (2009) 63, 1419?1424

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.