(12-03-10) Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan1,2,3

Taichi Shimazu, Manami Inoue, Shizuka Sasazuki, Motoki Iwasaki, Norie Sawada, Taiki Yamaji and Shoichiro Tsugane

1 From the EpidemiologyPrevention Division Research Center for Cancer PreventionScreening National Cancer Center Tokyo Japan.
2 Supported by a Grant-in-Aid for Cancer Research and for the Third Term Comprehensive Control Research for Cancer from the Ministry of Health, Labour, and Welfare of Japan and by Grant-in-Aid no. 20890291 for Young Scientists (Start-up) from the Ministry of Education, Culture, Sports, Science, and Technology and the Japan Society for the Promotion of Science.
3 Address correspondence to T Shimazu, Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku Tokyo, 104-0045 Japan. E-mail: [email protected] .
for the Japan Public Health Center?based Prospective Study Group
Background: Although case-control studies support the idea that soy foods or isoflavone intake is associated with a decreased risk of lung cancer, little evidence is available from prospective cohort studies. Moreover, no prospective study has addressed this association in men.
Objective: We investigated the association between isoflavone intake and lung cancer incidence.
Design: We conducted a population-based prospective cohort study in 36,177 men and 40,484 women aged 45?74 y with no history of cancer at baseline in 1995?1999. Participants responded to a validated questionnaire, which included 138 food items. We used Cox proportional hazards regression analysis to estimate the hazard ratios (HRs) and 95% CIs of lung cancer incidence according to isoflavone intake, which was estimated by genistein content from soy foods.
Results: During 11 y (671,864 person-years) of follow-up, we documented 481 male and 178 female lung cancer cases. In men we found an inverse association between isoflavone intake and risk of lung cancer in never smokers (n = 13,051; multivariate HR in the highest compared with the lowest quartile of isoflavone intake: 0.43; 95% CI: 0.21, 0.90; P for trend = 0.024) but not in current or past smokers. A similar, nonsignificant inverse association was seen in never-smoking women (n = 38,211; HR: 0.67; 95% CI: 0.41, 1.10; P for trend = 0.135). We also tested effect modification by smoking status (P for interaction = 0.085 in men and 0.055 in men and women combined).
Conclusion: In a large-scale, population-based, prospective study in Japan, isoflavone intake was associated with a decreased risk of lung cancer in never smokers.

Source: Am J Clin Nutr 91: 722-728, 2010

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