(01-12-05) Red wine acutely reduces arterial stiffness in CAD patients

NEW YORK (Reuters Health) - Drinking red wine, even dealcoholized red wine, acutely induces favorable effects on arterial hemodynamics in patients with coronary artery disease (CAD), according to a study conducted in Greece.

"We found that both types of red wine (regular or dealcoholized) reduce arterial stiffness in CAD patients which lasts for 90 minutes post-consumption," Dr. Emmanouil N. Karatzis from Alexandra University Hospital in Athens told Reuters Health.
"This is very important considering the fact that CAD patients' vessels are already stiff and this is a major cause of increased blood pressure and consequently increased risk for cardiovascular events," the researcher added.
The fact that both types of red wine reduced arterial stiffness indicates that this effect could possibly be attributed to red wine's antioxidants and not only to alcohol. "It is possible that antioxidants contained in red wine are very powerful and extremely significant for vessel function as we and other groups of investigators have shown," Dr. Karatzis said.
The findings of their double-blind crossover study involving 15 CAD patients are reported in the September issue of the American Journal of Hypertension. Dr. Karatzis' team monitored arterial stiffness and wave reflections, expressed as augmentation index, as well as central and peripheral BP at fasting and 30, 60, and 90 minutes after consumption of 250 mL of regular or non-alcoholic red wine.
Both regular and non-alcoholic red wine significantly decreased the augmentation index by 10.5% and 6.1%, respectively, the investigators report. A significant reduction in arterial stiffness as well as central systolic but not peripheral systolic blood pressure was also observed.
Specifically, central systolic BP fell 7.4 mm Hg and 5.4 mm Hg after consumption of red wine and non-alcoholic red wine, respectively.
Dr. Karatzis and colleagues emphasize that more study is needed to "clarify the exact mechanisms underlying the present observations." It may be worthwhile to take direct measurements of total antioxidant capacity or isoprostanes early after drinking red wine.
They also make the point that whether long-term use of red wine, with or without alcohol, leads to an improvement in large artery properties, and to a decrease in cardiovascular risk in patients with CAD, remains to be explored.

Source : Am J Hypertens 2005;18:1161-1167.

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.