(13-05-10) Risk of Colon Cancer and Coffee, Tea, and Sugar-Sweetened Soft Drink Intake: Pooled Analysis of Prospective Cohort Studies.

Zhang X, Albanes D, Beeson WL, van den Brandt PA, Buring JE, Flood A, Freudenheim JL, Giovannucci EL, Goldbohm RA, Jaceldo-Siegl K, Jacobs EJ, Krogh V, Larsson SC, Marshall JR, McCullough ML, Miller AB, Robien K, Rohan TE, Schatzkin A, Sieri S, Spiegelman D, Virtamo J, Wolk A, Willett WC, Zhang SM, Smith-Warner SA.

Affiliations of authors: Department of Nutrition (XZ, ELG, WCW, SAS-W), Department of Epidemiology (XZ, JEB, ELG, DS, WCW, SAS-W), and Department of Biostatistics (DS), Harvard School of Public Health, Boston, MA; Nutritional Epidemiology Branch (DA) and Division of Cancer Epidemiology and Genetics, Department of Health and Human Services (AS), National Cancer Institute, National Institute of Health, Bethesda, MD; The Center for Health Research, Loma Linda University School of Public Health, Loma Linda, CA (WLB, KJ-S); Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands (PAvdB); Division of Preventive Medicine, Department of Medicine (JEB, SMZ) and Channing Laboratory, Department of Medicine (ELG, WCW), Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Department of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, NY (JLF); Department of Food and Chemical Risk Analysis, TNO Quality of Life, Zeist, the Netherlands (RAG); Division of Epidemiology and Community Health, School of Public Health and Masonic Cancer Center, University of Minnesota, Minneapolis, MN (AF, KR); Department of Epidemiology, American Cancer Society, Atlanta, GA (EJJ, MLM); Nutritional Epidemiology Unit, National Cancer Institute, Milan, Italy (VK, SS); Division of Nutritional Epidemiology, National Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden (SCL, AW); Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY (JRM); Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada (ABM); Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY (TER); Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland (JV).
Abstract
Background The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved. Methods We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731 441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided. Results Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, P(trend) = .68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, P(trend) = .01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, P(trend) = .91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P > .20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P > .05). Conclusions Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study.

Source: J Natl Cancer Inst. 2010 May 7

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