(15-05-10) Obesity, insulin resistance and pregnancy outcome.

Catalano PM.
P Catalano, Department of Reproductive Biology, Case Western Reserve University, MetroHealth Medical Center, Cleveland, United States.

Abstract
There has been a significant increase over the past few decades in the number of reproductive age women who are either overweight or obese. Overweight and obese women are at increased risk for having decreased insulin sensitivity as compared with lean or average weight women. The combination of obesity and decreased insulin sensitivity increases the long term risk of these individuals developing the metabolic syndrome and associated problems of diabetes, hypertension, hyperlipidemia and cardiovascular disorders. Because of the metabolic alterations during normal pregnancy, particularly the 60% decrease in insulin sensitivity, overweight and obese women are at increased risk of metabolic dysregulation in pregnancy, i.e. gestational diabetes, preeclampsia, and fetal overgrowth. Hence pregnancy can be considered a metabolic stress test for the future risk of the metabolic syndrome. In this chapter we will review the underlying pathophysiology related to these disorders. More importantly, an understanding of these risks provides an opportunity for prevention. For example, a planned pregnancy offers an opportunity to address weight control prior to conception. At the very least, by avoiding excessive weight gain during pregnancy, this may prevent excessive weight retention post partum. Finally based on the concept of in utero programming, these lifestyle measures may not only have short and long term benefits for the women but also for her offspring as well.

Source: Reproduction. 2010 May 10.

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.