(16-06-10)Dietary intake of n-3 long-chain polyunsaturated fatty acids and coronary events in Norwegian patients with coronary artery disease.

Manger MS, Strand E, Ebbing M, Seifert R, Refsum H, Nordrehaug JE, Nilsen DW,
Drevon CA, Tell GS, Bleie O, Vollset SE, Pedersen ER, Nyg?rd O.

Section for Cardiology Institute of Medicine University of Bergen Bergen
Norway.
Abstract
BACKGROUND: Consumption of fish and n-3 (omega-3) long-chain polyunsaturated
fatty acids (LCPUFAs) has been associated with reduced risk of coronary artery
disease (CAD) mortality. OBJECTIVE: The aim was to examine the relation between
dietary intake of n-3 LCPUFAs or fish and risk of future coronary events or
mortality in patients with well-characterized CAD. DESIGN: This was a substudy
of 2412 participants in the Western Norway B Vitamin Intervention Trial with a
median follow-up time of 57 mo. Patients aged >18 y diagnosed with CAD (81%
men) completed a food-frequency questionnaire at baseline, from which daily
intakes of eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids as
well as fish were estimated on the basis of diet and intakes of supplements
including fish and cod liver oils. The main endpoint was a composite of
coronary events, including coronary death, nonfatal acute myocardial
infarction, and unstable angina pectoris. RESULTS: The mean (+/-SD) intakes of
n-3 LCPUFAs in quartiles 1-4 were 0.58 +/- 0.29, 0.83 +/- 0.30, 1.36 +/- 0.44,
and 2.64 +/- 1.18 g/d, respectively. We found no dose-response relation between
quartiles of n-3 LCPUFAs (based on intake as percentage of total energy) or
fish and coronary events or separate endpoints. A post hoc additive
proportional hazards model showed a slightly increased risk of coronary events
at an intake of n-3 LCPUFAs < approximately 0.30 g/d. CONCLUSION: Among
Norwegian patients with CAD consuming relatively high amounts of n-3 LCPUFAs
and fish, there were no significant trends toward a reduced risk of coronary
events or mortality with increasing intakes. This trial was registered at
clinicaltrials.gov as NCT00354081.

Source: Am J Clin Nutr. 2010 May 19. [Epub ahead of print]

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