(22-06-10) The effects of exercise-induced weight loss on appetite-related peptides and motivation to eat.

Martins C, Kulseng B, King NA, Holst JJ, Blundell JE.

Obesity Research Group, Department of Cancer Research and Molecular Medicine,
Faculty of Medicine, Norwegian University of Science and Technology, 7489
Trondheim, Norway. [email protected]
Abstract
CONTEXT: The magnitude of exercise-induced weight loss depends on the extent
of compensatory responses. An increase in energy intake is likely to result
from changes in the appetite control system toward an orexigenic environment;
however, few studies have measured how exercise impacts on both orexigenic and
anorexigenic peptides. OBJECTIVE: The aim of the study was to investigate the
effects of medium-term exercise on fasting/postprandial levels of appetite-
related hormones and subjective appetite sensations in overweight/obese
individuals. DESIGN AND SETTING: We conducted a longitudinal study in a
university research center. PARTICIPANTS AND INTERVENTION: Twenty-two sedentary
overweight/obese individuals (age, 36.9 +/- 8.3 yr; body mass index, 31.3 +/-
3.3 kg/m(2)) took part in a 12-wk supervised exercise programme (five times per
week, 75% maximal heart rate) and were requested not to change their food
intake during the study. MAIN OUTCOME MEASURES: We measured changes in body
weight and fasting/postprandial plasma levels of glucose, insulin, total
ghrelin, acylated ghrelin (AG), peptide YY, and glucagon-like peptide-1 and
feelings of appetite. RESULTS: Exercise resulted in a significant reduction in
body weight and fasting insulin and an increase in AG plasma levels and fasting
hunger sensations. A significant reduction in postprandial insulin plasma
levels and a tendency toward an increase in the delayed release of glucagon-
like peptide-1 (90-180 min) were also observed after exercise, as well as a
significant increase (127%) in the suppression of AG postprandially.
CONCLUSIONS: Exercise-induced weight loss is associated with physiological and
biopsychological changes toward an increased drive to eat in the fasting state.
However, this seems to be balanced by an improved satiety response to a meal
and improved sensitivity of the appetite control system.

Source: J Clin Endocrinol Metab. 2010 Apr;95(4):1609-16. Epub 2010 Feb 11.

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