(08-07-10) Polyphenols Halt Prostate Cancer Growth

Scientists believe they now know exactly why polyphenols, such as those found
in red wine and green tea, inhibit cancer growth. The antioxidants produce a
combined effect to disrupt an important cell signaling pathway necessary for
prostate cancer growth.
The SphK1/S1P signaling pathway plays a role both in prostate cancer and in
other cancers such as colon cancer, breast cancer, and gastric cancers.
Eurekalert reports:
"Scientists conducted in vitro experiments which showed that the inhibition of
the sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway was
essential for green tea and wine polyphenols to kill prostate cancer cells ...
Human prostate cancer cells were implanted in the mice and results showed a
dramatic decrease in tumor size in the mice drinking the EGCG or polyphenon E
mixtures."


Sources:
Eurekalert June 9, 2010
The FASEB Journal June 3, 2010

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