(12-07-10) Carbohydrate nutrition and inflammatory disease mortality in older adults.

Buyken AE, Flood V, Empson M, Rochtchina E, Barclay AW, Brand-Miller J,
Mitchell P.

Centre for Vision Research, Department of Ophthalmology and Westmead
Millennium Institute, University of Sydney, Sydney, Australia.
Abstract
BACKGROUND: Several studies suggest that carbohydrate nutrition is related to
oxidative stress and inflammatory markers. OBJECTIVE: We examined whether
dietary glycemic index (GI), dietary fiber, and carbohydrate-containing food
groups were associated with the mortality attributable to noncardiovascular,
noncancer inflammatory disease in an older Australian cohort. Design: Analysis
included 1490 postmenopausal women and 1245 men aged >/=49 y at baseline (1992-
1994) from a population-based cohort who completed a validated food-frequency
questionnaire. Cox proportional hazards ratios were calculated both for death
from diseases in which inflammation or oxidative stress was a predominant
contributor and for cardiovascular mortality. RESULTS: Over a 13-y period, 84
women and 86 men died of inflammatory diseases. Women in the highest GI tertile
had a 2.9-fold increased risk of inflammatory death compared with women in the
lowest GI tertile [multivariate hazard ratio in energy-adjusted tertile 3
(tertile 1 as reference): 2.89; 95% CI: 1.52, 5.51; P for trend: 0.0006,
adjusted for age, smoking, diabetes, and alcohol and fiber consumption].
Increasing intakes of foods high in refined sugars or refined starches (P =
0.04) and decreasing intakes of bread and cereals (P = 0.008) or vegetables
other than potatoes (P = 0.007) also independently predicted a greater risk,
with subjects' GI partly explaining these associations. In men, only an
increased consumption of fruit fiber (P = 0.005) and fruit (P = 0.04) conferred
an independent decrease in risk of inflammatory death. No associations were
observed with cardiovascular mortality. CONCLUSION: These data provide new
epidemiologic evidence of a potentially important link between GI and
inflammatory disease mortality among older women.

Source: Am J Clin Nutr. 2010 Jun 23. [Epub ahead of print]

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