(19-07-10) Inflammatory markers are increased in youth with type 1 diabetes: the SEARCH Case-Control study.

Snell-Bergeon JK, West NA, Mayer-Davis EJ, Liese AD, Marcovina SM, D'Agostino
RB Jr, Hamman RF, Dabelea D.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, P.
O. Box 6511, Mail Stop A-140, Aurora, Colorado 80045, USA. janet.snell-
[email protected]
Abstract
CONTEXT: Increased inflammation may contribute to type 1 diabetes (T1D)
complications. OBJECTIVE: The objective of the study was to investigate the
association of inflammation with obesity, hyperglycemia and dyslipidemia in
youth with T1D. DESIGN: This was a cross-sectional study of youth with and
without T1D. SETTING: The study was conducted in Colorado and South Carolina.
PATIENTS: SEARCH Case-Control participants with T1D [n = 553, mean age 15 yr
(range 10-22), median duration 2.7 yr] and without diabetes [n = 215, mean age
15 yr (range 10-22)]. INTERVENTION: This was an observational study. MAIN
OUTCOME MEASURES: IL-6, high-sensitivity C-reactive protein (hsCRP),
fibrinogen, and leptin were measured. RESULTS: Inflammatory markers were
evaluated by diabetes status, quartiles of glycated hemoglobin, and obesity
using multiple linear regression analyses, adjusted for age, sex, study site,
race/ethnicity, T1D duration, body mass index, and pubertal status. Compared
with controls, youth with T1D had higher IL-6 and fibrinogen levels at all
levels of glycemia and obesity, and hsCRP levels were significantly higher in
youth with T1D in the top three quartiles of glycated hemoglobin (> or = 7.2%)
and among normal-weight subjects. Leptin was lower in youth with poor glycemic
control. Higher hsCRP and fibrinogen were correlated with higher total and LDL
cholesterol, and apolipoprotein B in youth with T1D, whereas higher fibrinogen
was correlated with higher LDL and apolipoprotein B in controls. CONCLUSIONS:
T1D is characterized by excess inflammation, independent of adiposity and
glycemic control. Even T1D youth in good glycemic control had higher levels of
IL-6 and fibrinogen than controls. Elevated inflammatory markers were
associated with an atherogenic lipid profile, which may contribute to
accelerated atherosclerosis in youth with T1D.

Source: J Clin Endocrinol Metab. 2010 Jun;95(6):2868-76. Epub 2010 Apr 6.

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