(27-07-10) Fetal exposure to maternal type 1 diabetes is associated with renal dysfunction at adult age.

Abi Khalil C, Travert F, Fetita S, Rouzet F, Porcher R, Riveline JP, Hadjadj S, Larger E, Roussel R, Vexiau P, Le Guludec D, Gautier JF, Marre M.

1: Diabetes Department, Groupe Hospitalier Bichat - Claude Bernard, Assistance Publique - H?pitaux de Paris, Paris, France.
Abstract
AbstractObjectives: In animal studies, hyperglycemia during fetal development reduces nephron numbers. We tested if this observation translates into renal dysfunction in humans by studying renal functional reserve in adult offspring exposed in utero to maternal type 1 diabetes. Research Design and Methods: We compared 19 non-diabetic offspring of type 1 diabetic mothers to 18 offspring of type 1 diabetic fathers (controls). Glomerular filtration rate ((51)Cr-EDTA clearance), effective renal plasma flow ((123)I-Hippurate clearance), mean arterial pressure, and renal vascular resistances were measured at baseline and during amino acid infusion, which mobilizes renal functional reserve. Results: Offspring of type 1 diabetic mothers were similar to controls for age (27 (range 18-41) years), sex, body mass index (23.1+/- 3.7 kg/m(2)), and birth weight (3288+/-550 vs 3440+/-489 grams). During amino acid infusion, glomerular filtration rate and effective renal plasma flow increased less in offspring of type 1 diabetic mothers than in controls: from 103 +/- 14 to 111 +/- 17 ml/min (+8+/-13%) vs from 108 +/- 17 to 128 +/- 23 ml/min (+19+/-7 %, p=0.009), and from 509 +/- 58 to 536 +/- 80 ml/min (+5+/-9%) vs from 536 +/- 114 to 620 +/- 140 ml/min, (+16+/-11 %, p=0.0035). Mean arterial pressure and renal vascular resistances declined less than in controls: +2+/-5 vs -2+/-3 % (p=0.019), and +3+/-9 vs -14+/-8 % (p=0.001). Conclusions: Reduced functional reserve may reflect a reduced number of nephrons, undergoing individually hyperfiltration. If so, offspring of type 1 diabetic mothers may be predisposed to glomerular and vascular diseases.

Source: Diabetes. 2010 Jul 9. [Epub ahead of print]

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.