(03-09-10) Physical activity, adiposity and diabetes risk in middle-aged and older Chinese population: The Guangzhou Biobank cohort study.

Qin L, Corpeleijn E, Jiang C, Thomas GN, Schooling CM, Zhang W, Cheng KK,
Leung GM, Stolk RP, Lam TH.

Department of Epidemiology, University Medical Center of Groningen, University
of Groningen, The Netherlands.
Abstract
AbstractObjective - Physical activity may modify the association of adiposity
with type 2 diabetes. We investigated the independent and joint association of
adiposity and physical activity with fasting plasma glucose, impaired fasting
glucose and type 2 diabetes in a Chinese population. Research design and
methods - Middle-aged and older Chinese(n=28,946>/=50 years, 72.4%women) from
the Guangzhou Biobank Cohort Study were examined in 2003-2008. Multivariable
regression was used in a cross-sectional analysis. Results - BMI, waist
circumference(WC) and waist-to-hip ratio(WHR) were positively associated with
type 2 diabetes after multiple adjustment, most strongly for WHR with odds ratio
(OR)3.99(95% confidence interval (CI):3.60-4.42) for highest compared with
lowest tertile. Lack of moderate-to-vigorous physical activity (OR 1.29(1.17-
1.41)), but not walking, was associated with diabetes. The association of
moderate-to-vigorous activity with fasting glucose varied with WHR tertiles(P=0.
01 for interaction). Within the high WHR tertile, participants who were lack of
moderate-to-vigorous activity had an OR 3.87(3.22-4.65) for diabetes, whereas
for those who were active had an OR 2.94(2.41-3.59). Conclusions - In this
population, WHR was a better measure of adiposity-related diabetes risk than
BMI or WC. Higher moderate-to-vigorous activity was associated with lower
diabetes risk, especially in abdominally obese individuals.

Source: Diabetes Care. 2010 Aug 16.

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