(19-09-10) Magnesium Intake in Relation to Systemic Inflammation, Insulin Resistance, and the Incidence of Diabetes.

Kim DJ, Xun P, Liu K, Loria C, Yokota K, Jacobs DR Jr, He K.

1. Department of Nutrition, Gillings School of Global Public Health and School
of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Abstract
AbstractObjective. To investigate the long-term associations of magnesium
intake with incidence of diabetes, systemic inflammation and insulin resistance
among young American adults. Research design and methods. A total of 4,497
Americans, aged 18-30 years, who had no diabetes at baseline, were
prospectively examined for incident diabetes based on quintiles of magnesium
intake. We also investigated the associations between magnesium intake and
inflammatory markers, i.e., high-sensitivity C-reactive protein (hs-CRP),
interleukin-6 (IL-6), and fibrinogen, and the homeostasis model assessment of
insulin resistance (HOMA-IR). Results. During 20-year follow-up, 330 incident
diabetic cases were identified. Magnesium intake was inversely associated with
incidence of diabetes after adjustment for potential confounders. The
multivariable-adjusted hazard ratio of diabetes for participants in the highest
quintile of magnesium intake was 0.53 (95% confidence interval, 0.32-0.86; P
(trend)<0.01) compared with those in the lowest quintile. Consistently,
magnesium intake was significantly inversely associated with hs-CRP, IL-6,
fibrinogen, and HOMA-IR; and serum magnesium levels were inversely correlated
with hs-CRP and HOMA-IR. Conclusions. Magnesium intake was inversely
longitudinally associated with incidence of diabetes in young American adults.
This inverse association may be explained, at least in part, by the inverse
correlations of magnesium intake with systemic inflammation and insulin
resistance.

Source: Diabetes Care. 2010 Aug 31. [Epub ahead of print]

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