(20-09-10) Effects of thyroid hormone on glycated hemoglobin and glycated albumin levels in non-diabetic subjects with overt hypothyroidism.

Kim MK, Kwon HS, Baek KH, Lee JH, Park WC, Sohn HS, Lee KW, Song KH.

Department of Internal Medicine.
Abstract
AbstractObjective: We aimed to determine the effects of thyroid hormone on
glycated hemoglobin (A1C) and glycated albumin (GA) in non-diabetic patients
with overt hypothyroidism. Research Design and Methods: A1C levels were
measured in 45 non-diabetic patients with overt hypothyroidism and 180
euthyroid controls. A1C, GA, fasting blood glucose (FBS), 1,5-anhydroglucitol
and erythrocyte indexes were determined in 30 non-diabetic patients with overt
hypothyroidism before and after thyroid hormone replacement. Results: A1C
levels were higher in patients with hypothyroidism compared with controls. A1C
levels were decreased by thyroid hormone replacement. Thyroid hormone
replacement increased serum erythropoietin, reticulocyte count, and mean
corpuscular hemoglobin (MCH). The change in A1C level was significantly
correlated with the change in reticulocyte count or MCH. Thyroid hormone
replacement decreased serum levels of albumin and GA. However, FBS and 1,5-
anhydroglucitol levels were not altered. Conclusions: Levels of A1C and GA are
spuriously high in non-diabetic patients with overt hypothyroidism.

Source: Diabetes Care. 2010 Sep 7. [Epub ahead of print]

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