(20-09-10) Antidepressant Medication Use, Weight Gain and Risk of Type 2 Diabetes Mellitus: A Population-based Study.

Kivim?ki M, Hamer M, Batty GD, Geddes JR, Tabak AG, Pentti J, Virtanen M, Vahtera J.

From Department of Epidemiology and Public Health, University College London,
UK.
Abstract
AbstractObjective- To examine antidepressant medication use as a risk factor
for type 2 diabetes and weight gain. Research design and methods- A series of
nested studies within a prospective cohort of 151,347 working-aged men and
women including 9197 participants with continuing antidepressant medication,
224 with severe depression, and 851 with incident type 2 diabetes mellitus
during a mean follow-up of 4.8 years, as indicated by national health and
prescription registers (the Public Sector study, Finland 1995-2005). Results-
In the first analysis, the cases were individuals with incident type 2 diabetes
compared with matched diabetes-free controls. Antidepressant use of >/=200
defined daily doses was associated with a doubling of diabetes risk in both
participants with no indication of severe depression (odds ratio 1.93, 95% CI
1.48-2.51) and participants with severe depression (odds ratio 2.65 95% CI 1.31-
5.39). In the further analyses, exposed group was antidepressant users and
reference group non-users matched for depression-related characteristics. The 5-
year absolute risk of diabetes was 1.1% for non-users, 1.7% for individuals
treated with 200-399 defined daily doses a year, and 2.3% for those with >/=400
defined daily doses (p(trend)<0.0001). An average self-reported weight gain,
based on repeated surveys, was 1.4 kg (2.5%) among non-users and 2.5 kg (4.3%)
among users of >/=200 defined daily doses (p(trend)<0.0001). Separate analyses
for tricyclic antidepressants and selective-serotonin-re-uptake inhibitors
replicated these findings. Conclusions- In these data, continuing use of
antidepressant medication was associated with an increased relative risk of
type 2 diabetes, although the elevation in absolute risk was modest.

Source: Diabetes Care. 2010 Sep 7. [Epub ahead of print]

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