(22-09-10) Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer:

a pooled analysis of prospective cohort studies.


Park Y, Spiegelman D, Hunter DJ, Albanes D, Bergkvist L, Buring JE, Freudenheim JL, Giovannucci E, Goldbohm RA, Harnack L, Kato I, Krogh V, Leitzmann MF, Limburg PJ, Marshall JR, McCullough ML, Miller AB, Rohan TE, Schatzkin A, Shore R, Sieri S, Stampfer MJ, Virtamo J, Weijenberg M, Willett WC, Wolk A, Zhang SM, Smith-Warner SA.
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA, 02115, USA.
Abstract
OBJECTIVE: To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer.
METHODS: Using the primary data from 13 cohort studies, we estimated study- and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model.
RESULTS: Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, >4,000 vs. 600 vs. 200 vs. CONCLUSIONS: Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study.

Source: Cancer Causes Control. 2010 Sep 5

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