(23-09-10) Carbohydrate nutrition and inflammatory disease mortality in older adults1,2,3

Anette E Buyken, Victoria Flood, Marianne Empson, Elena Rochtchina, Alan W Barclay, Jennie Brand-Miller and Paul Mitchell
1 From the Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute (AEB, VF, ER, and PM), and the Boden Institute of Obesity, Nutrition and Exercise (AEB, VF, AWB, and JB-M), University of Sydney, Sydney, Australia; the School of Health Sciences, Faculty of Health and Behavioural Sciences, University of Wollongong, Wollongong, Australia (VF); the Immunology Department, Auckland City Hospital, Auckland, New Zealand (ME); and the Research Institute of Child Nutrition, Rheinische Friedrich-Wilhelms-Universitaumlt Bonn, Dortmund, Germany (AEB).
2 Supported by the Australian National Health and Medical Research Council (project grant nos. 211069 and 457349) and a research grant from the Heinrich-Hertz Stiftung, North-Rhine Westphalia, Germany (to AEB).
3 Address correspondence to P Mitchell, Department of Ophthalmology, University of Sydney, Centre for Vision Research, Westmead Millennium Institute, Hawkesbury Road, Westmead, New South Wales 2145, Australia. E-mail: [email protected] .
Background: Several studies suggest that carbohydrate nutrition is related to oxidative stress and inflammatory markers.
Objective: We examined whether dietary glycemic index (GI), dietary fiber, and carbohydrate-containing food groups were associated with the mortality attributable to noncardiovascular, noncancer inflammatory disease in an older Australian cohort.
Design: Analysis included 1490 postmenopausal women and 1245 men aged ge 49 y at baseline (1992?1994) from a population-based cohort who completed a validated food-frequency questionnaire. Cox proportional hazards ratios were calculated both for death from diseases in which inflammation or oxidative stress was a predominant contributor and for cardiovascular mortality.
Results: Over a 13-y period, 84 women and 86 men died of inflammatory diseases. Women in the highest GI tertile had a 2.9-fold increased risk of inflammatory death compared with women in the lowest GI tertile [multivariate hazard ratio in energy-adjusted tertile 3 (tertile 1 as reference): 2.89; 95% CI: 1.52, 5.51; P for trend: 0.0006, adjusted for age, smoking, diabetes, and alcohol and fiber consumption]. Increasing intakes of foods high in refined sugars or refined starches (P = 0.04) and decreasing intakes of bread and cereals (P = 0.008) or vegetables other than potatoes (P = 0.007) also independently predicted a greater risk, with subjectsrsquo GI partly explaining these associations. In men, only an increased consumption of fruit fiber (P = 0.005) and fruit (P = 0.04) conferred an independent decrease in risk of inflammatory death. No associations were observed with cardiovascular mortality.
Conclusion: These data provide new epidemiologic evidence of a potentially important link between GI and inflammatory disease mortality among older women.

Source: Am J Clin Nutr 92: 634-643, 2010

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.