(26-09-10) Menarchal Timing in Type 1 Diabetes through the Last Four Decades.

Schweiger B, Klingensmith GJ, Snell-Bergeon JK.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver,
The Children's Hospital Aurora, Colorado USA.
Abstract
AbstractObjective- We sought to examine whether age at menarche has changed
over the past 4 decades by comparing age at menarche by year of diagnosis with
type 1 diabetes (T1DM). Research Design and Methods- This was a cross sectional
study of age at menarche in two cohorts: adolescents (ages 11- 24 years,
n=228), and adults (ages 19-55 years, n=290, enrolled in the Coronary Artery
Calcification in Type 1 Diabetes study). Results- The adolescent cohort
reported a younger age of menarche than the adult women with TIDM (12.69 ? 0.08
years vs. 13.22 ? .12 yrs, mean? SE, P< 0.001). Age at menarche was later in
both adolescent girls and adult women with T1DM diagnosed prior to menarche
(12.82 ? 1.16 and 13.7 ? 2.23, mean? SE) than for those diagnosed after
menarche (12.12 ? 1.25 and 12.65 ? 1.38, mean? SE, P<0.001 for both). Age at
menarche was then examined by decade of T1DM diagnosis (1970-79, 1980-89, 1990-
99, and 2000-09). Age at menarche significantly declined over the four decades
(P=0.0002). However, the delay in menarche among girls diagnosed with T1DM
before menarche compared to those diagnosed after menarche was also significant
across all decades (P<0.0001), and did not change significantly over time (P=0.
41 for interaction of cohort and diagnosis pre-menarche). Conclusions- Age at
menarche has declined over the past 4 decades among girls with T1DM, but a
delay in age at menarche among those diagnosed prior to menarche compared to
those diagnosed after menarche remains.

Source: Diabetes Care. 2010 Sep 15. [Epub ahead of print]

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