(26-09-10) Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition cohort study.

Michaud DS, Gallo V, Schlehofer B, Tj?nneland A, Olsen A, Overvad K, Dahm CC,
Teucher B, Lukanova A, Boeing H, Sch?tze M, Trichopoulou A, Lagiou P, Kyrozis
A, Sacerdote C, Krogh V, Masala G, Tumino R, Mattiello A, Bueno-de-Mesquita HB,
Ros MM, Peeters PH, van Gils CH, Skeie G, Engeset D, Parr CL, Ardanaz E,
Chirlaque MD, Dorronsoro M, S?nchez MJ, Arg?elles M, Jakszyn P, Nilsson LM,
Melin BS, Manjer J, Wirf?lt E, Khaw KT, Wareham N, Allen NE, Key TJ, Romieu I,
Vineis P, Riboli E.

Department of Epidemiology and Public Health, Imperial College, London, United
Kingdom and the Department of Clinical Sciences in Malm?/Nutrition
Epidemiology, Lund University, Malm?, Sweden.
Abstract
BACKGROUND: In a recent US cohort study, total coffee and tea consumption was
inversely associated with risk of glioma, and experimental studies showed that
caffeine can slow the invasive growth of glioblastoma.

OBJECTIVE: The objective was to examine the relation between coffee and tea
intake and the risk of glioma and meningioma in a large European cohort study,
the European Prospective Investigation into Cancer and Nutrition (EPIC).

DESIGN: Data on coffee and tea intake were collected from men and women
recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up,
343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9
countries. We used Cox proportional hazards models to examine the relation
between coffee and tea and brain tumors.

RESULTS: We observed no associations between coffee, tea, or combined coffee
and tea consumption and risk of either type of brain tumor when using quantiles
based on country-specific distributions of intake. However, a significant
inverse association was observed for glioma risk among those consuming ≥100 mL
coffee and tea per day compared with those consuming <100 mL/d (hazard ratio:
0.66; 95% CI: 0.44, 0.97; P = 0.03). The association was slightly stronger in
men (hazard ratio: 0.59; 95% CI: 0.34, 1.01) than in women (hazard ratio: 0.74;
95% CI: 0.42, 1.31), although neither was statistically significant.

CONCLUSIONS: In this large cohort study, we observed an inverse association
between total coffee and tea consumption and risk of glioma that was consistent
with the findings of a recent study. These findings, if further replicated in
other studies, may provide new avenues of research on gliomas.

Source: Am J Clin Nutr. 2010 Sep 15. [Epub ahead of print]

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