(01-10-10) Plasma vitamin D and mortality in older men: a community-based prospective cohort study1,2,3

Karl Micha?lsson, John A Baron, Greta Snellman, Rolf Gedeborg, Liisa Byberg, Johan Sundstr?m, Lars Berglund, Johan ?rnl?v, Per Hellman, Rune Blomhoff, Alicja Wolk, Hans Garmo, Lars Holmberg and H?kan Melhus
1 From the Uppsala Clinical Research Center (KM, RG, L Byberg, JS, L Berglund, and HM) and the Section of Orthopedics, Department of Surgical Sciences (KM, GS, and L Byberg), Uppsala University, Uppsala, Sweden; the Departments of Medicine, and of Community and Family Medicine, Dartmouth Medical School, Hanover, NH (JAB); the Section of Anaesthesiology and Intensive Care, Department of Surgical Sciences (RG); the Section of Acute Medicine, Department of Medical Sciences (JS); and the Section of Geriatrics, Department of Public Health and Caring Sciences (J?), Uppsala University, Uppsala, Sweden; the Department of Health and Social Sciences, H?gskolan Dalarna, Falun, Sweden (J?); the Section of Surgery, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden (PH); the Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway (RB); the National Institute of Environmental Medicine, Karolinska Institutet Stockholm, Sweden (AW); the Division of Cancer Studies, School of Medicine, King's College, London, United Kingdom (HG and LH); the Regional Oncologic Center, Uppsala University, Uppsala, Sweden (HG and LH); and the Section of Clinical Pharmacology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden (HM).
2 Supported by research grants from the Swedish Research Council (K2009-52X-13511-10-3 and K2008-52X-12671-11-3).
3 Address correspondence to K Micha?lsson, Department of Surgical Sciences and Uppsala Clinical Research Center, Uppsala University, SE-751 85 Uppsala, Sweden. E-mail: [email protected] .
Background: Vitamin D status is known to be important for bone health but may also affect the development of several chronic diseases, including cancer and cardiovascular diseases, which are 2 major causes of death.
Objective: We aimed to examine how vitamin D status relates to overall and cause-specific mortality.
Design: The Uppsala Longitudinal Study of Adult Men, a community-based cohort of elderly men (mean age at baseline: 71 y; n = 1194), was used to investigate the association between plasma 25-hydroxyvitamin D [25(OH)D] and mortality. Total plasma 25(OH)D was determined with HPLC atmospheric pressure chemical ionization mass spectrometry. Proportional hazards regression was used to compute hazard ratios (HRs).
Results: During follow-up (median: 12.7 y), 584 (49%) participants died. There was a U-shaped association between vitamin D concentrations and total mortality. An approximately 50% higher total mortality rate was observed among men in the lowest 10% (<46 nmol/L) and the highest 5% (>98 nmol/L) of plasma 25(OH)D concentrations compared with intermediate concentrations. Cancer mortality was also higher at low plasma concentrations (multivariable-adjusted HR: 2.20; 95% CI: 1.44, 3.38) and at high concentrations (HR: 2.64; 95% CI: 1.46, 4.78). For cardiovascular death, only low (HR: 1.89; 95% CI: 1.21, 2.96) but not high (HR: 1.33; 95% CI: 0.69, 2.54) concentrations indicated higher risk.
Conclusions: Both high and low concentrations of plasma 25(OH)D are associated with elevated risks of overall and cancer mortality. Low concentrations are associated with cardiovascular mortality.

Source: Am J Clin Nutr 92: 841-848, 2010.

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.