(03-10-10) THE IMPACT OF BODY MASS INDEX AND THE METABOLIC SYNDROME ON THE RISK OF DIABETES IN MIDDLE-AGED MEN.

Arnl?v J, Sundstr?m J, Ingelsson E, Lind L.

Department of Public Health and Caring Sciences/Geriatrics.
Abstract
AbstractObjective: The existence of an obese sub-group, with a healthy
metabolic profile and low diabetes risk, has been proposed. Yet, long term data
is lacking. We aimed to investigate associations between combinations of body
mass index (BMI)-categories and metabolic syndrome (MetS), and risk of type 2
diabetes in middle-aged men. Research design and methods: At age 50,
cardiovascular risk factors were assessed in 1675 participants without diabetes
in the community-based ULSAM-study. According to BMI/MetS-status, they were
categorized as normal weight (BMI<25 kg/m(2)) without MetS (NCEP-criteria,
n=853), normal weight with MetS (n=60), overweight (BMI 25-30 kg/m(2)) without
MetS (n=557), overweight with MetS (n=117), obese (BMI>30 kg/m(2)) without MetS
(n=28), and obese with MetS (n=60). We investigated the associations between
BMI/MetS-categories at baseline and diabetes incidence. Results: After 20
years, 160 participants had developed diabetes. In logistic regression models
adjusting for age, smoking, and physical activity, increased risks for diabetes
were observed in normal-weight with MetS (odds ratio [OR] 3.28, 95%CI 1.38-
7.81, p=0.007), overweight without MetS (OR 3.49, 95%CI 2.26-5.42, p<0.001),
overweight with MetS (OR 7.77, 95%CI 4.44-13.62, p<0.001), obese without MetS
(OR 11.72, 95%CI 4.88-28.16, p<0.001) and obese with MetS (OR 10.06, 95%CI 5.19-
19.51, p<0.001), compared to normal-weight without MetS. Conclusions:
Overweight or obese men without MetS, were at increased risk for diabetes. Our
data provide further evidence that overweight and obesity in the absence of the
MetS should not be considered a harmless condition.

Source: Diabetes Care. 2010 Sep 17. [Epub ahead of print]

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