(17-10-10) Changes in alcohol consumption and subsequent risk of type 2 diabetes in men.

Joosten MM, Chiuve SE, Mukamal KJ, Hu FB, Hendriks HF, Rimm EB.

Department of Nutrition, Harvard School of Public Health, Boston,
Massachusetts.
Abstract
AbstractObjective The objective of this study was to investigate the
association of four-year changes in alcohol consumption with subsequent risk of
type 2 diabetes. Research Design and Methods We prospectively examined 38,031
men from the Health Professionals Follow-up Study free of diagnosed diabetes or
cancer in 1990. Alcohol consumption was reported on food frequency
questionnaires and updated every four years. Results A total of 1905 cases of
type 2 diabetes occurred during 428,497 person-years of follow-up. A 7.5 g/day
(??half a glass) increase in alcohol consumption over four years was associated
with lower diabetes risk among initial nondrinkers (multivariable hazard ratio
[HR] 0.78; 95% confidence interval [CI] 0.60-1.00) and drinkers initially
consuming <15 g/day (HR 0.89; 95% CI 0.83-0.96) but not among men initially
drinking ??15 g/day (HR 0.99; 95% CI 0.95-1.02; P(interaction) < 0.01). A
similar pattern was observed for levels of total adiponectin and hemoglobin A
(1c), with a better metabolic profile among abstainers and light drinkers who
modestly increased their alcohol intake, compared with men who either drank
less or among men who were already moderate drinkers and increased their
intake. Likewise, compared to stable light drinkers (0-4.9 g/day), light
drinkers who increased their intake to moderate levels (5.0-29.9 g/day) had a
significantly lower risk of type 2 diabetes (HR 0.75; 95% CI 0.62-0.90).
Conclusions Increases in alcohol consumption over time were associated with
lower risk of type 2 diabetes among initially rare and light drinkers. This
lower risk was evident within a four-year period following increased alcohol
intake.

Source: Diabetes. 2010 Sep 28. [Epub ahead of print]

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