(25-10-10) Vitamin D deficiency and anthropometric indicators of adiposity in school-age children: a prospective study.

Gilbert-Diamond D, Baylin A, Mora-Plazas M, Marin C, Arsenault JE, Hughes MD, Willett WC, Villamor E.
Departments of Nutrition and Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI.
Abstract
BACKGROUND: Cross-sectional studies have indicated that vitamin D serostatus is inversely associated with adiposity. It is unknown whether vitamin D deficiency is a risk factor for the development of adiposity in children.
OBJECTIVE: We investigated the associations between vitamin D serostatus and changes in body mass index (BMI; in kg/m(2)), skinfold-thickness ratio (subscapular-to-triceps), waist circumference, and height in a longitudinal study in children from Bogota, Colombia.
DESIGN: We quantified plasma 25-hydroxyvitamin D [25(OH)D] concentrations in baseline samples of a randomly selected group of 479 schoolchildren aged 5-12 y and classified vitamin D status as deficient [25(OH)D concentrations <50 nmol/L], insufficient [25(OH)D concentrations ??50 and <75 nmol/L], or sufficient [25(OH)D concentrations ??75 nmol/L]. We measured anthropometric variables annually for a median of 30 mo. We estimated the average change in each anthropometric indicator according to baseline vitamin D status by using multivariate mixed linear regression models.
RESULTS: Vitamin D-deficient children had an adjusted 0.1/y greater change in BMI than did vitamin D-sufficient children (P for trend = 0.05). Similarly, vitamin D-deficient children had a 0.03/y (95% CI: 0.01, 0.05/y) greater change in subscapular-to-triceps skinfold-thickness ratio and a 0.8 cm/y (95% CI: 0.1, 1.6 cm/y) greater change in waist circumference that did vitamin D-sufficient children. Vitamin D deficiency was related to slower linear growth in girls (-0.6 cm/y, P = 0.04) but not in boys (0.3 cm/y, P = 0.34); however, an interaction with sex was not statistically significant.
CONCLUSION: Vitamin D serostatus was inversely associated with the development of adiposity in school-age children

Source: Am J Clin Nutr. 2010 Oct 6

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