(31-10-10) ACG: Type of Liver Cancer Tied to Obesity, Diabetes

Another study finds obesity also linked to an increased risk of colorectal
adenoma recurrence



Obesity and insulin resistance appear to be associated with an increased risk
of non-cirrhotic hepatocellular carcinoma, with obesity also tied to an
elevated risk of colorectal adenoma recurrence, according to two studies
presented at the annual scientific meeting of the American College of
Gastroenterology, held from Oct. 15 to 20 in San Antonio.
MONDAY, Oct. 18 (HealthDay News) -- Obesity and insulin resistance appear to
be associated with an increased risk of non-cirrhotic hepatocellular carcinoma
(HCC), with obesity also tied to an elevated risk of colorectal adenoma
recurrence, according to two studies presented at the annual scientific meeting
of the American College of Gastroenterology, held from Oct. 15 to 20 in San
Antonio.

To assess the association of non-cirrhotic HCC with body mass index (BMI) and
diabetes, Benjamin Mitlyng, M.D., of the University of Minnesota in
Minneapolis, and colleagues evaluated 12 patients with non-cirrhotic HCC who
underwent partial hepatectomy between January 2008 and September 2009. Despite
a lack of steatosis, the investigators found that patients with non-cirrhotic
HCC had a high prevalence of diabetes and elevated BMIs. However, despite the
presence of advanced disease in some patients, those who underwent resection
experienced minimal complications, tolerated the procedure well, had no
operative mortality, and experienced an average tumor-free follow-up of 17.5
months.

As part of the Polyp Prevention Trial, Adeyinka Laiyemo, M.D., of the National
Cancer Institute in Bethesda, Md., and colleagues evaluated the cumulative risk
of colorectal adenoma recurrence associated with obesity. At baseline, about
one-half of the 760 participants were overweight (BMI, 25 to 29 kg/m?) and one-
fourth were obese (BMI, 30 kg/m?). Over a follow-up of 8.4 years, the
investigators found that overweight and obese patients had an elevated risk of
adenoma recurrence over both the short and long term.

"Since BMI was positively associated with adenoma recurrence in [the] short
and long term, lifestyle modification should be encouraged," Laiyemo said in a
statement.

Source:
http://www.doctorslounge.com/index.php/news/pb/14927

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