(07-11-10) Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC)

cohort study1,2,3

Dominique S Michaud, Valentina Gallo, Brigitte Schlehofer, Anne Tj?nneland, Anja Olsen, Kim Overvad, Christina C Dahm, Birgit Teucher, Annekatrin Lukanova, Heiner Boeing, Madlen Sch?tze, Antonia Trichopoulou, Pagona Lagiou, Andreas Kyrozis, Carlotta Sacerdote, Vittorio Krogh, Giovanna Masala, Rosario Tumino, Amalia Mattiello, H Bas Bueno-de-Mesquita, Martine M Ros, Petra HM Peeters, Carla H van Gils, Guri Skeie, Dagrun Engeset, Christine L Parr, Eva Ardanaz, Maria-Dolores Chirlaque, Miren Dorronsoro, Maria Jos? S?nchez, Marcial Arg?elles, Paula Jakszyn, Lena M Nilsson, Beatrice S Melin, Jonas Manjer, Elisabet Wirf?lt, Kay-Tee Khaw, Nick Wareham, Naomi E Allen, Timothy J Key, Isabelle Romieu, Paolo Vineis and Elio Riboli
Background: In a recent US cohort study, total coffee and tea consumption was inversely associated with risk of glioma, and experimental studies showed that caffeine can slow the invasive growth of glioblastoma.
Objective: The objective was to examine the relation between coffee and tea intake and the risk of glioma and meningioma in a large European cohort study, the European Prospective Investigation into Cancer and Nutrition (EPIC).
Design: Data on coffee and tea intake were collected from men and women recruited into the EPIC cohort study. Over an average of 8.5 y of follow-up, 343 cases of glioma and 245 cases of meningioma were newly diagnosed in 9 countries. We used Cox proportional hazards models to examine the relation between coffee and tea and brain tumors.
Results: We observed no associations between coffee, tea, or combined coffee and tea consumption and risk of either type of brain tumor when using quantiles based on country-specific distributions of intake. However, a significant inverse association was observed for glioma risk among those consuming 100 mL coffee and tea per day compared with those consuming <100 mL/d (hazard ratio: 0.66; 95% CI: 0.44, 0.97; P = 0.03). The association was slightly stronger in men (hazard ratio: 0.59; 95% CI: 0.34, 1.01) than in women (hazard ratio: 0.74; 95% CI: 0.42, 1.31), although neither was statistically significant.
Conclusions: In this large cohort study, we observed an inverse association between total coffee and tea consumption and risk of glioma that was consistent with the findings of a recent study. These findings, if further replicated in other studies, may provide new avenues of research on gliomas.

Source: American Journal of Clinical Nutrition, V l. 92, No. 5, 1145-1150, November 2010

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