(16-11-10) Severe Periodontitis is Associated With Diastolic Blood Pressure Elevation in Individuals With .......

Severe Periodontitis is Associated With Diastolic Blood Pressure Elevation in Individuals With Heterozygous Familial Hypercholesterolemia: A Pilot Study.


Vieira CL, Cury PR, Miname MH, Martinez LR, Bortolotto LA, Giuliano I, Santos RD, Caramelli B.
Heart Institute, University of S?o Paulo Medical School, S?o Paulo, Brazil.
Abstract
Background - This pilot study evaluated the association of severe periodontitis with pulse wave velocity (PWV), carotid artery intima-media thickness (IMT), clinical, metabolic and atherogenic inflammatory markers in 79 Heterozygous Familial Hypercholesterolemia (hFH) subjects, all free of previous manifestations of vascular disease. Methods - Body mass index (BMI- kg/m(2)), plasma lipids, glucose, C-reactive protein (CRP) and white blood cell count (WBC) were evaluated. After a full-mouth periodontal examination, the patients were categorized into Severe Periodontitis group (SPG) or Non-severe Periodontitis group (NSPG). Results - SPG showed significantly higher values of cholesterol years score, triglycerides, glucose, PWV, IMT and diastolic blood pressure (DBP) (p≤ 0.05). After adjustment for traditional risk factors for atherosclerosis, only the association between severe periodontitis and DBP (OR 3.1, CI 1.1-8.5, p = 0.03) was confirmed. Conclusion - In individuals with hFH, severe periodontitis is associated with higher diastolic blood pressure, which suggests that severe periodontitis itself may contribute to the worst cardiovascular risk profile in this population.

Source: J Periodontol. 2010 Nov 8.

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