(18-11-10) Effects of high-whey-protein intake and resistance training on renal, bone and metabolic parameters in rats.

Aparicio VA, Nebot E, Porres JM, Ortega FB, Heredia JM, L?pez-Jurado M,
Ram?rez PA.

Department of Physiology, School of Pharmacy and Institute of Nutrition and
Food Technology, University of Granada, Campus Universitario de Cartuja s/n,
Granada 18071, Spain.
Abstract
Consumption of high-protein (HP) diets is postulated to exert a negative
influence on bone and renal health. However, no conclusive evidence has been
presented related to this issue or to the potential protective action of
resistance training on HP-induced systemic effects. We examined the effects of
HP diet consumption on food intake, body-weight gain, body composition, and
renal, bone and metabolic parameters of rats performing resistance training. A
total of ninety-six adult male Wistar rats were randomly distributed in twelve
experimental groups (n 8): normal-protein (10 %) or HP (45 %) diets, with or
without resistance training, killed for experimental periods of 1, 2 or 3
months. Diets were based on a commercial whey protein hydrolysate. Consumption
of HP diets and resistance training significantly affected food intake, body
weight and body composition, as well as the plasma levels of total cholesterol,
HDL-cholesterol and TAG. The buffering action of resistance training on such
diet-induced alterations was especially evident in the levels of plasma TAG.
Consumption of HP diets led to a considerable increase in kidney weight,
urinary volume and acidity, as well as in the urinary excretion of Ca, with a
parallel reduction in the urinary excretion of citrate (P < 0?05). No apparent
deleterious effect on bone mineral content was found. In conclusion,
consumption of HP diets caused alterations in renal health status and some
metabolic parameters, but did not seem to affect bone status. Resistance
training had a protective action against alterations of renal health status and
some metabolic parameters such as plasma TAG.


Source: Br J Nutr. 2010 Nov 9:1-10.

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