(14-12-10) Plasma and dietary magnesium and risk of sudden cardiac death in women.

Chiuve SE, Korngold EC, Januzzi JL Jr, Gantzer ML, Albert CM.

Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women's
Hospital and Harvard Medical School, Boston, MA.
Abstract
BACKGROUND: Magnesium has antiarrhythmic properties in cellular and
experimental models; however, its relation to sudden cardiac death (SCD) risk
is unclear.

OBJECTIVE: We prospectively examined the association between magnesium, as
measured in diet and plasma, and risk of SCD.

DESIGN: The analysis was conducted within the Nurses' Health Study. The
association for magnesium intake was examined prospectively in 88,375 women who
were free of disease in 1980. Information on magnesium intake, other nutrients,
and lifestyle factors was updated every 2-4 y through questionnaires, and 505
cases of sudden or arrhythmic death were documented over 26 y of follow-up. For
plasma magnesium, a nested case-control analysis including 99 SCD cases and 291
controls matched for age, ethnicity, smoking, and presence of cardiovascular
disease was performed.

RESULTS: After multivariable adjustment for confounders and potential
intermediaries, the relative risk of SCD was significantly lower in women in
the highest quartile compared with those in the lowest quartile of dietary
(relative risk: 0.63; 95% CI: 0.44, 0.91) and plasma (relative risk: 0.23; 95%
CI: 0.09, 0.60) magnesium. The linear inverse relation with SCD was strongest
for plasma magnesium (P for trend = 0.003), in which each 0.25-mg/dL (1 SD)
increment in plasma magnesium was associated with a 41% (95% CI: 15, 58%) lower
risk of SCD.

CONCLUSIONS: In this prospective cohort of women, higher plasma concentrations
and dietary magnesium intakes were associated with lower risks of SCD. If the
observed association is causal, interventions directed at increasing dietary or
plasma magnesium might lower the risk of SCD.

Source: Am J Clin Nutr. 2010 Nov 24.

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