(28-01-11) Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II Study.

Fransson EI, Batty GD, Tab?k AG, Brunner EJ, Kumari M, Shipley MJ, Singh-
Manoux A, Kivim?ki M.

Department of Epidemiology and Public Health, University College London, 1-19
Torrington Place, London WC1E 6BT, United Kingdom. [email protected]
Abstract
CONTEXT: Obesity is associated with low-grade inflammation, but the long-term
effects of weight change on inflammation are unknown.

OBJECTIVE: The aim was to examine the association of change in weight, body
mass index (BMI), and waist circumference with change in C-reactive protein
(CRP) and IL-6 and to assess whether this association is modified by baseline
obesity status.

DESIGN AND SETTING: The design was a prospective cohort study among civil
servants (the Whitehall II Study, UK). We used data from two clinical
screenings carried out in 1991-1993 and 2002-2004 (mean follow-up, 11.3 yr).

PARTICIPANTS: We studied 2496 men and 1026 women [mean age, 49.4 (sd=6.0) yr
at baseline] with measurements on inflammatory markers and anthropometry at
both baseline and follow-up.

MAIN OUTCOME MEASURES: We measured change in serum CRP and IL-6 during follow-
up.

RESULTS: The mean increases in CRP and IL-6 were 0.08 [95% confidence interval
(CI), 0.07-0.09] mg/liter and 0.04 (95% CI, 0.03-0.05) pg/ml per 1-kg increase
in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at
baseline had an average increase in CRP of 0.06 (95% CI, 0.05-0.08) mg/liter
per 1-kg increase in body weight, whereas the increase in those who were
overweight (25≤BMI<30 kg/m2) and obese (BMI≥30 kg/m2) was greater: 0.08 (95%
CI, 0.06-0.09) mg/liter and 0.11 (95% CI, 0.07-0.14) mg/liter, respectively (P
value for interaction=0.002). Similar patterns were observed for changes in BMI
and waist circumference.

CONCLUSIONS: Those who were overweight or obese at baseline had a greater
absolute increase in CRP per unit increase in weight, BMI, and waist
circumference than people who were normal weight.

Source: J Clin Endocrinol Metab. 2010 Dec;95(12):5370-4. Epub 2010 Aug 18.

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