(03-02-11) Heart Rate Recovery After Exercise Is a Predictor of Silent Myocardial Ischemia in Patients With Type 2 Diabetes.

Yamada T, Yoshitama T, Makino K, Lee T, Saeki F.

Department of Cardiology, Toshiba Hospital, Tokyo, Japan.
Abstract
OBJECTIVE Slow heart rate recovery (HRR) predicts all-cause mortality. This
study investigated the relationship between silent myocardial ischemia (SMI)
and HRR in type 2 diabetes. RESEARCH DESIGN AND METHODS The study enrolled 87
consecutive patients with type 2 diabetes and no chest symptoms. They underwent
treadmill exercise testing and single-photon emission computed tomography
imaging with thallium scintigraphy. Patients with abnormal myocardial perfusion
images also underwent coronary angiography. RESULTS SMI was diagnosed in 41
patients (47%). The SMI group showed slower HRR than the non-SMI group (18 ? 6
vs. 30 ? 12 bpm; P < 0.0001). HRR was significantly associated with SMI (odds
ratio 0.83 [95% CI 0.75-0.92]; P = 0.0006), even after adjustment for maximal
exercise workload, resting heart rate, maximum heart rate, rate pressure
product, HbA(1c), use of sulfonamides, and a history of cardiovascular disease.
CONCLUSIONS HRR can predict SMI in patients with type 2 diabetes.

Sources:
PMID: 21266655 [PubMed - as supplied by publisher]
Diabetes Care. 2011 Jan 25. [Epub ahead of print]

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