(18-02-11) Molecular Mechanism of Vitamin D in the Cardiovascular System.

Li YC.
From the Department of Medicine, The University of Chicago, Chicago, IL.
Abstract
Vitamin D deficiency is a global health problem that has various adverse consequences. Vitamin D is mainly synthesized in the skin by sunlight (UV light) irradiation; therefore, the vitamin D status is influenced by geographic locations, seasonal changes and skin pigmentations. The kidney is involved in the biosynthesis of 1,25-dihydroxyvitamin D and the reuptake of filtered 25-hydroxyvitamin D from the proximal tubules, thus vitamin D deficiency is highly prevalent in patients with kidney disease who suffer renal insufficiency. There is a growing body of epidemiological and clinical evidence in the literature that links vitamin D deficiency to cardiovascular disease. The discovery of the vitamin D hormone functioning as an endocrine inhibitor of the renin-angiotensin system provides an explanation for this association. This review will discuss the mechanism underlying the connection between vitamin D and cardiovascular disease and its physiological and therapeutic implications.

Source: J Investig Med. 2011 Feb 8.

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