(19-02-11) High-Normal HbA1c Is a Strong Predictor of Type 2 Diabetes in the General Population.

Bonora E, Kiechl S, Mayr A, Zoppini G, Targher G, Bonadonna RC, Willeit J.

Section of Endocrinology and Metabolism, Department of Medicine, University of
Verona and Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
Abstract
OBJECTIVE Glycosylated hemoglobin (HbA(1c)) recently has been recommended for
the diagnosis of diabetes by the American Diabetes Association, but its value
in the prediction of type 2 diabetes is poorly understood. In this study, we
evaluated how high-normal HbA(1c) levels predict type 2 diabetes. RESEARCH
DESIGN AND METHODS We measured HbA(1c) in 919 Caucasian subjects, aged 40-79
years, and recorded new cases of type 2 diabetes in the following 15 years.
Diabetes was diagnosed with HbA(1c). RESULTS Subjects were stratified according
to baseline HbA(1c) (<5.0, 5.00-5.49 [reference], 5.50-5.99, and 6.00-6.49%).
Sex- and age-adjusted hazard ratios (95% CI) for type 2 diabetes were 1.11
(0.30-4.41), 1.00, 3.79 (1.79-8.06), and 12.50 (5.51-28.34), respectively.
Results did not change after adjusting for several putative confounding factors
and were confirmed when models with updated variables were used. CONCLUSIONS HbA
(1c) is an independent risk factor for type 2 diabetes. Subjects with high-
normal levels of HbA(1c) deserve particular attention because they have a
strong risk of developing diabetes.

Sources:
Diabetes Care. 2011 Feb 9. [Epub ahead of print]
PMID: 21307378 [PubMed - as supplied by publisher]

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