(22-02-11) Adherence to a Mediterranean diet and plasma fatty acids: data from the Bordeaux sample of the Three-City study.

F?art C, Torr?s MJ, Samieri C, Jutand MA, Peuchant E, Simopoulos AP, Barberger-
Gateau P.

Equipe Epid?miologie de la Nutrition et des Comportements Alimentaires,
INSERM, U897, Universit? Victor S?galen Bordeaux 2, ISPED Case 11, 146 rue L?o-
Saignat, F-33076 Bordeaux Cedex, France.
Abstract
Higher adherence to a Mediterranean diet (MeDi) and n-3 PUFA may both
contribute to decreased dementia risk, but the association between MeDi
adherence and lipid status is unclear. The aim of the present study was to
analyse the relationship between plasma fatty acids and MeDi adherence in
French elderly community dwellers. The study population (mean age 75?9 years)
consisted of 1050 subjects from Bordeaux (France) included in the Three-City
cohort. Adherence to the MeDi (scored as 0-9) was computed from a FFQ and 24 h
recall. The proportion of each plasma fatty acid was determined. Cross-
sectional analysis of the association between plasma fatty acids and MeDi
adherence was performed by multi-linear regression. After adjusting for age,
sex, energy intake, physical activity, smoking status, BMI, plasma TAG and apoE-
ɛ4 genotype, plasma palmitoleic acid was significantly inversely associated
with MeDi adherence, whereas plasma DHA, the EPA+DHA index and total n-3 PUFA
were positively associated with MeDi adherence. The n-6:n-3 PUFA, arachidonic
acid (AA):EPA, AA:DHA and AA:(EPA+DHA) ratios were significantly inversely
associated with MeDi adherence. Plasma EPA was positively associated with MeDi
adherence only in apoE-ɛ4 non-carriers. There was no association between MeDi
adherence and SFA and total MUFA. The present results suggest that the
protective effect of the MeDi on cognitive functions might be mediated by
higher plasma DHA and lower n-6:n-3 PUFA ratios.

Sources:
Br J Nutr. 2011 Feb 8:1-10. [Epub ahead of print]
PMID: 21303575 [PubMed - as supplied by publisher]

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