(23-03-11) Reliability of leptin, but not adiponectin, as a biomarker for diet-induced weight loss in humans.

Klempel MC, Varady KA.

Department of Kinesiology and Nutrition, University of Illinois at Chicago,
Chicago, Illinois, USA.
Abstract
Calorie restriction (CR)-induced weight loss has been shown to lower the risk
of chronic disease in obese individuals. Although the mechanisms that link
weight loss to disease risk reduction remain unclear, evidence suggests
adipokines may play a role. What has yet to be determined, however, is the dose-
response effect of body weight loss and visceral fat mass loss on adipokines.
Accordingly, this review examines how varying degrees of CR-induced weight loss
(i.e., >10%, 5-10%, and <5% from baseline) impact plasma levels and expression
of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8),
monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4).
The dose-response relationship between visceral fat mass loss and adipokine
profile improvement will also be explored. Results from this review demonstrate
that even mild weight loss induced by CR may have beneficial effects on leptin
levels, but it has no clear impact on adiponectin, resistin, IL-6, IL-8, MCP-1,
or RBP-4 concentrations.

Source: Nutr Rev. 2011 Mar;69(3):145-54. doi: 10.1111/j.1753-4887.2011.00373.x. Epub
2011 Feb 14.

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.