(25-03-11) Vitamin D deficiency in Spain: a population-based cohort study

I Gonz??lez-Molero, S Morcillo, S Vald??s, V P??rez-Valero, P Botas, E Delgado, D Hern??ndez, G Olveira, G Rojo, C Gutierrez-Repiso, E Rubio-Mart??n, E Men??ndez and F Soriguer
Abstract
Background:
Vitamin D deficiency is common worldwide. No homogenous reference values have yet been established and no studies of values have been conducted in Spain involving a large number of participants.
Objective:
To study the population concentrations of vitamin D in a representative sample of the Spanish population.
Subjects/Methods:
The study involved two cohorts from Spain, the Asturias study and the Pizarra study, which are two prospective, population-based studies involving 2260 participants. In 1262 subjects (age: 20?C83 years) we studied 25-hydroxyvitamin D, intact parathyroid hormone (iPTH), calcium, phosphorus and creatinine.
Results:
The median population values of 25-hydroxyvitamin D and iPTH were 22.46 ng/ml and 42.29 pg/ml, respectively. The values of 25-hydroxyvitamin D were significantly higher in summer and correlated with age (??=−0.05??0.01, P<0.0001), creatinine (??=6.42??1.17, P<0.0001) and iPTH (−0.07??0.01, P<0.0001), but not with calcium, phosphorus or sex. The increase in iPTH with age was seen whatever the values of 25-hydroxyvitamin D, and was greater in the older persons. The concentration of iPTH rose continuously with effect from 25-hydroxyvitamin D values below ??30 ng/ml. Values above ??35 ng/ml were associated with a significantly lower concentration of iPTH.
Conclusions:
One-third (33.9%) of the Spanish population may be at risk for Vitamin D deficiency. The 25-hydroxyvitamin D values above 30 ng/ml can safely discard ??hyper PTH??. The increase in iPTH concentration is greater in older persons for similar values of 25-hydroxyvitamin D.

Source: European Journal of Clinical Nutrition 65, 321-328 (March 2011)

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