(27-0311) Serum peptide YY in response to short-term overfeeding in young men1,2,3

1. Farrell Cahill,
2. Jennifer L Shea,
3. Edward Randell,
4. Sudesh Vasdev, and
5. Guang Sun
+ Author Affiliations
1. 1From the Division of Medicine, Faculty of Medicine (FC, JLS, SV, and GS), and the Discipline of Laboratory Medicine, Memorial University of Newfoundland, St John's, Canada (ER).
? ↵2 Supported by the Canadian Institutes for Health Research and the Canada Foundation for Innovation.
? ↵3 Address correspondence to G Sun, 300 Prince Philip Drive, Memorial University of Newfoundland, St John's, Newfoundland, Canada, A1B 3V6. E-mail: [email protected].
Abstract
Background: Peptide YY (PYY), a gut hormone that inhibits appetite, has been linked to the development of obesity.
Objective: This study investigated the nutritional regulation of PYY after 7 d of overfeeding (70% above normal energy requirements) in normal-weight, overweight, and obese men.
Design: Sixty-nine men (aged 19?29 y) participated in the study. We analyzed the relation between fasting serum PYY before and after a 7-d overfeeding challenge in normal-weight, overweight, and obese men. In addition, we analyzed PYY with obesity-related phenotypes including weight, percentage body fat (measured by dual-energy X-ray absorptiometry), body mass index (BMI), total cholesterol, HDL, LDL, glucose, insulin, insulin resistance, and ? cell function evaluated by the homeostasis model assessment of insulin resistance (HOMA-IR) and ? cell function (HOMA-?) at baseline and in response to the energy surplus.
Results: Fasting serum PYY concentrations at baseline were not significantly different between the normal-weight, overweight, and obese subjects on the basis of dual-energy X-ray absorptiometry or BMI. Although the PYY concentration significantly increased due to overfeeding, no differences were observed between adiposity statuses. In addition, basal PYY was negatively correlated with the changes of total cholesterol, HDL, and LDL in normal weight. In addition, the increase in PYY after overfeeding was positively correlated with HDL cholesterol and glucose in normal-weight subjects.
Conclusions: Our findings suggest that fasting PYY concentrations are not associated with adiposity status. Moreover, the 7-d overfeeding challenge significantly increased fasting PYY, which is likely a protective response to the positive energy balance.

Source: Am J Clin Nutr April 2011 vol. 93 no. 4 741-747

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