(01-04-11) More scientific evidence that antioxidants can fight cancer

by David Gutierrez, staff writer

(NaturalNews) For the first time, scientists have discovered a genetic pathway
suggesting that antioxidants may help in the treatment of cancer, according to
a study conducted by researchers from Thomas Jefferson University and published
in the journal Cancer Biology & Therapy.

Scientists have known for a long time that diets high in antioxidant-
containing foods are associated with a lower risk of cancer. This effect is
widely attributed to the fact that antioxidants remove DNA-damaging free
radicals from the body.

"Reactive oxygen species [free radicals] are formed in vivo during normal
aerobic metabolism and can cause damage to DNA, proteins, and lipids, despite
the natural antioxidant defense system of all organisms," writes Erich
Grotewold in the book The Science of Flavonoids.

"Diets high in flavonoids, fruits, and vegetables are protective against a
variety of diseases, particularly cardiovascular disease and some types of
cancer," he writes.

Yet now researchers have shown that antioxidants may not just prevent, but
also treat cancer. The Thomas Jefferson University researchers had previously
discovered a protein called Caveolin-1 (Cav-1) that, when present in the human
genome, suppresses tumor growth. Indeed, the presence or absence of the Cav-1
protein is the single best predictor of breast cancer outcome. Women with
triple-negative breast cancer - the most deadly kind - are more than 75 percent
likely to be alive 12 years after diagnosis if they have the protein, and less
than 10 percent likely to be alive five years after diagnosis if they lack it.

The researchers further verified that Cav-1 plays an antioxidant role in the
body. In the current study, the researchers confirmed that when Cav-1 is
removed, oxidative stress in breast cancer tumors increases, leading to a 300
percent increase in tumor mass and volume.

"Antioxidants have been associated with cancer reducing effects - beta
carotene, for example - but the mechanisms, the genetic evidence, has been
lacking," lead researcher Michael P. Lisanti said. "This study provides the
necessary genetic evidence that reducing oxidative stress in the body will
decrease tumor growth."

The findings may actually cast doubt on the effectiveness of many chemotherapy
drugs, which are actually known to increase oxidative stress. They also suggest
that many antioxidant drugs used to treat other conditions, such as diabetes
and malaria, may be effective in treating cancer.

To learn more about how to fight disease with a healthy diet, read the free
NaturalNews.com report "Nutrition Can Save America!" at
http://www.naturalnews.com/report_N....

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In evidenza

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