(02-05-11) Normal Fasting Plasma Glucose and Risk of Type 2 Diabetes.

Brambilla P, La Valle E, Falbo R, Limonta G, Signorini S, Cappellini F,
Mocarelli P.
Source
University Department of Laboratory Medicine, University Milano Bicocca,
Milano, Italy.

Abstract
OBJECTIVE To investigate the association of normal fasting plasma glucose
(FPG) and the risk for type 2 diabetes. RESEARCH DESIGN AND METHODS Data
concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at
least three times between 1992 and 2008 were extracted from a database. Three
FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional
hazards analysis was applied to estimate the risk of incident diabetes adjusted
for other risk factors. RESULTS During 108,061 person-years of follow-up (8,110
women and 5,735 men), 307 incident cases of type 2 diabetes were found. The
final model demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99
mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL. CONCLUSIONS Our data suggest that
FPG between 91 and 99 mg/dL is a strong independent predictor of type 2
diabetes and should be used to identify people to be further investigated and
aided with preventive measures.

Source: Diabetes Care. 2011 Apr 15. [Epub ahead of print]

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