(08-05-11) Obesity Augments Calcium-Induced Increases in Skeletal Calcium Retention in Adolescents.

Hill KM, Braun MM, Egan KA, Martin BR, McCabe LD, Peacock M, McCabe GP, Weaver
CM.
Source
Departments of Foods and Nutrition (K.M.H., M.K.A.E., B.R.M., L.D.M., C.M.W.)
and Statistics (G.P.M.), Purdue University, West Lafayette, Indiana 47906; and
Indiana University School of Medicine (K.M.H., M.P.), Indianapolis, Indiana
46202.
Abstract
Context: Overweight adolescents have low bone mineral content for weight and
are at increased risk for fractures. Objective: The aim was to determine
whether overweight and obesity influence the positive relationship between
dietary calcium intake and skeletal calcium retention in adolescents. Design:
Analysis of pooled data from calcium balance studies in adolescents. Setting:
Participants each underwent a 3-wk calcium balance study in a controlled
environment. Participants: Participants included 280 White, Black, and Asian
boys (n = 73) and girls (n = 207) ages 10-16 yr. Main Outcome Measure: The
relationship among body mass index (BMI), calcium intake, and calcium retention
was modeled using linear regression. Results: Calcium intake, BMI, sex, race,
and age explained 27.9% of the variation in calcium retention. At low calcium
intakes, there was no effect of BMI on skeletal calcium retention, but at
higher calcium intakes, BMI increased skeletal calcium retention. Conclusions:
Greater gains in calcium retention occur with increases in calcium intake in
adolescents with higher BMI compared with those with lower BMI. Additional
studies are needed to investigate whether increasing calcium intake reduces the
increased risk of fracture associated with overweight and obesity in
adolescents.

Source: J Clin Endocrinol Metab. 2011 Apr 13. [Epub ahead of print]
PMID: 21490075 [PubMed - as supplied by publisher]

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