(11-05-11) Vitamin D Deficiency Is Associated With Retinopathy in Children and Adolescents With Type 1 Diabetes.

Kaur H, Donaghue KC, Chan AK, Benitez-Aguirre P, Hing S, Lloyd M, Cusumano J,
Pryke A, Craig ME.
Source
School of Women's and Children's Health, University of New South Wales, New
South Wales, Australia.
Abstract
OBJECTIVE To examine the hypothesis that vitamin D deficiency (VDD) is
associated with an increased prevalence of microvascular complications in young
people with type 1 diabetes. RESEARCH DESIGN AND METHODS In a cross-sectional
study of 517 patients, 25-hydroxyvitamin D was measured. Retinopathy was
assessed by 7-field stereoscopic retinal photography, peripheral neuropathy by
thermal and vibration threshold testing, and microalbuminuria by albumin
excretion rate or albumin-to-creatinine ratio. RESULTS Retinopathy prevalence
was higher in cases with VDD versus sufficiency (18 vs. 9%, P = 0.02);
deficiency was not associated with microalbuminuria or neuropathy. In logistic
regression, retinopathy was associated with VDD (odds ratio 2.12 [95% CI 1.03-
4.33]), diabetes duration (1.13, 1.05-1.23), and HbA(1c) (1.24, 1.02-1.50).
CONCLUSIONS VDD is associated with an increased prevalence of retinopathy in
young people with type 1 diabetes. The inflammatory and angiogenic effects of
VDD may contribute to early retinal vascular damage; however, further
investigations are warranted.

Source: Diabetes Care. 2011 Apr 22. [Epub ahead of print]

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