(14-05-11) Trans fatty acids, insulin resistance and diabetes

A K Thompson1, A-M Minihane1,2 and C M Williams1
1Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutrition Science, University of Reading, Reading, UK

Correspondence: Dr AK Thompson, Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK. E-mail [email protected]
2Current address: Diet and Health Group, School of Medicine, Health Policy and Practice, University of East Anglia (UEA), Norwich NR4 7TJ, UK.
Received 20 May 2010; Revised 23 September 2010; Accepted 23 September 2010; Published online 27 October 2010.
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Abstract
The possible relationship between consumption of trans fatty acids (TFAs) and risk of insulin resistance or development of diabetes mellitus type II has been considered by a number of human and animal studies over the past decade. This review evaluates the evidence, and concludes that there is limited evidence for a weak association at high TFA intakes, but very little convincing evidence that habitual exposure as part of a standard western diet has a significant contribution to risk of diabetes or insulin resistance. The possibility of increased risk for individuals with particular genotypes (such as the FABP2 Thr54 allele) is of interest, but further work would be required to provide sufficient evidence of any association.

Source: European Journal of Clinical Nutrition (2011) 65, 553?564

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