(03-06-11) Vitamin D and Chronic Lung Disease: A Review of Molecular Mechanisms and Clinical Studies1,2

James D. Finklea,3 Ruth E. Grossmann,5 and Vin Tangpricha4?6*
3Division of Pulmonary, Allergy, and Critical Care Medicine and 4Division of Endocrinology, Diabetes and Lipids, Emory University School of
Medicine, and 5Nutrition and Health Sciences Program, Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322; and
6Atlanta VA Medical Center, Atlanta, GA 30033
ABSTRACT
Abstract:
Vitamin D is classically recognized for its role in calcium homeostasis and skeletal metabolism. Over the last few decades, vitamin D deficiency has
increased in prevalence in adults and children. Potential extraskeletal effects of vitamin D have been under investigation for several diseases.
Several cross-sectional studies have associated lower vitamin D status with decreased lung function. This finding has prompted investigators to
examine the association of vitamin D deficiency with several chronic lung diseases. One major focus has been the link between maternal vitamin
D status and childhood asthma. Vitamin D deficiency has also been associated with increased risk of respiratory infection from influenza A and
Mycobacterium tuberculosis. Other chronic respiratory diseases associated with vitamin D deficiency include cystic fibrosis, interstitial lung disease,
and chronic obstructive pulmonary disease. This review will examine the current clinical literature and potential mechanisms of vitamin D in
various pulmonary diseases.

Source: Adv. Nutr. 2: 244?253, 2011.

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