(02-07-11) Effects of weight loss on serum vitamin D in postmenopausal women1,2,3,4,5

1. Caitlin Mason,
2. Liren Xiao,
3. Ikuyo Imayama,
4. Catherine R Duggan,
5. Carolyn Bain,
6. Karen E Foster-Schubert,
7. Angela Kong,
8. Kristin L Campbell,
9. Ching-Yun Wang,
10. Marian L Neuhouser,
11. Li Li,
12. Robert W Jeffery,
13. Kim Robien,
14. Catherine M Alfano,
15. George L Blackburn, and
16. Anne McTiernan
+ Author Affiliations
1. 1From the Fred Hutchinson Cancer Research Center, Seattle, WA (CM, LX, II, CRD, CB, C-YW, MLN, and AM); the University of Washington, Seattle, WA (KEF-S, C-YW, MLN, and AM); the University of Illinois at Chicago, Chicago, IL (AK); the University of British Columbia, Vancouver, British, Columbia (KLC); the Case Western Reserve University, Cleveland, OH (LL); the University of Minnesota, Minneapolis, MN (RWJ and KR); the Office of Cancer Survivorship, National Cancer Institute, Bethesda, MD (CMA); and the Division of Nutrition, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA (GLB).
+ Author Notes
?? ↵2 While working on the trial, CMA was employed at the Ohio State University and located to the National Cancer Institute (NCI) after completion of her effort on the Nutrition and Exercise in Women (NEW) trial.
?? ↵3 None of the funding agencies was involved in the trial design or conduct.
?? ↵4 Supported by grants NIH R01 CA102504 and NIH U54-CA116847. KEF-S was supported by grant NIH 5KL2RR025015-03. AK was supported by grants NCI R25 CA94880 and NCI 2R25CA057699-16. CM and KLC were supported by a Canadian Institutes of Health Research Fellowship Award.
?? ↵5 Address correspondence to A McTiernan, Prevention Center, Fred Hutchinson Cancer Research Center, M4-B874, PO Box 19024, Seattle, WA 98109. E-mail: [email protected].
Abstract
Background: Low concentrations of circulating vitamin D are common with obesity and may represent a potential mechanism explaining the elevated risk of certain cancers and cardiovascular outcomes observed in individuals who are overweight or obese.
Objective: The objective of this study was to investigate the effects of 12 mo of weight loss through caloric restriction, exercise intervention, or both on serum 25-hydroxyvitamin D [25(OH)D] concentrations.
Design: Overweight and obese postmenopausal women (n = 439) were randomly assigned to 1 of 4 groups: 1) diet modification (n = 118), 2) exercise (n = 117), 3) diet + exercise (n = 117), or 4) control (n = 87). The diet intervention was a group-based reduced-calorie program with a 10% weight-loss goal. The exercise intervention consisted of 45 min of moderate-to-vigorous intensity aerobic activity daily for 5 d/wk. Serum 25(OH)D concentrations were measured by using a competitive chemiluminescent immunoassay at baseline and 12 mo.
Results: No significant change in serum 25(OH)D was found between the intervention and control groups. Women who lost <5%, 5?C9.9%, 10?C14.9%, or ??15% of baseline weight had mean increases in 25(OH)D of 2.1, 2.7, 3.3, and 7.7 ng/mL, respectively (P for trend = 0.002). Baseline vitamin D status did not modify the effect of the interventions on weight loss or body-composition changes at the 12-mo follow-up.
Conclusion: A greater degree of weight loss, achieved through either a reduced-calorie diet or increased exercise, is associated with increased circulating 25(OH)D concentrations. This trial is registered at clinicaltrials.gov as NCT00470119.

Source: Am J Clin Nutr July 2011 vol. 94 no. 1 95-103

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.