(03-07-11) Be Vigilant for New-Onset Diabetes with High-Dose Statins, Meta-Analysis Suggests

Compared with moderate-dose regimens, high-dose statins are associated with increased diabetes risk, according to a JAMA meta-analysis.
Researchers studied outcomes from five trials comparing high- versus moderate-dose statins in some 33,000 patients free of diabetes at baseline. During a mean follow-up of almost 5 years, the risk for new-onset diabetes was higher in the high-dose group (odds ratio, 1.12). The risk for cardiovascular events was, conversely, lower in the high-dose group (OR, 0.84). The authors estimate that 498 patients per year would need to take high-dose statins to cause one additional case of diabetes. To prevent one cardiovascular event, 155 patients would need to be treated.
Although the authors have not identified a mechanism for this effect, they "suggest that clinicians should be vigilant for the development of diabetes in patients receiving intensive statin therapy."

Source: JAMA article (Free abstract)

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