(29-10-11) Resveratrol lowers breast cancer risk by blocking estrogen growth factor

by John Phillip

(NaturalNews) Researchers from the Faculty of Pharmacy at the University of
Calabria in Italy publishing in The FASEB Journal report that resveratrol
blocks the effect of estrogen and can help to prevent the malignant growth of
breast cancer in women. The grape/red wine derivative has been the subject of
numerous scientific studies in recent years and has shown promise in lowering
risks from cardiovascular disease, cancer and dementia. Scientists also believe
the protective nutrient may extend healthy lifespan by directly influencing
mortality genes known as SIRT. Health-minded adults will want to include
resveratrol from natural food sources or supplementation to reap the numerous
health benefits.

To design their study, researchers used several breast cancer cell lines
expressing the estrogen receptor to test the effects of resveratrol. They
exposed the different cells to a solution containing resveratrol and compared
the results to cells left untreated. They found an important reduction in cell
growth in cells treated with resveratrol, while no changes were seen in
untreated cells. Further experiments determined that this effect was caused by
a critical reduction in estrogen receptors caused by the administration of
resveratrol.

Resveratrol Supplementation Suppresses the Growth of Malignant Breast Cancer
Cells
This finding is the first of its kind as it relates specifically to the effect
of resveratrol on a particular cancer cell line. The team was able to conclude
that resveratrol is able to counteract the malignant progression of breast
cancer cells by inhibiting the growth and spread of hormone resistant cancerous
cells. This has important implications for the treatment of women with breast
cancer whose tumors eventually develop resistance to hormonal therapy.

A peer review board examining the study data concluded "scientists haven't
finished distilling the secrets of good health that have been hidden in natural
products such as red wine." It is important to note that in this body of
research, resveratrol only demonstrated an effect on malignant cancer cells and
exerted no effect on non-cancerous cells.

While the authors cautioned that people should not go out and start using red
wine or resveratrol supplements as a treatment for breast cancer, the finding
strongly indicates that the plant-protective compound should be considered as a
component in an overall plan designed to prevent the devastating disease.
Nutrition experts recommend a supplemental intake (from a purified, organically
derived source) of between 50 and 250 mg per day for optimal health benefits.

Sources for this article include:
http://www.fasebj.org/content/25/10...
http://www.sciencedaily.com/release...
http://www.medicalnewstoday.com/rel...

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