(11-11-11) Enteral n-3 fatty acids and micronutrients enhance percentage of positive neutrophil and lymphocyte adhesion molecules: a potential

Enteral n-3 fatty acids and micronutrients enhance percentage of positive neutrophil and lymphocyte adhesion molecules: a potential mediator of pressure ulcer healing in critically ill patients.

Theilla M, Schwartz B, Zimra Y, Shapiro H, Anbar R, Rabizadeh E, Cohen J, Singer P.
Source
Department of General Intensive Care, Institute for Nutrition Research, Rabin
Medical Center, Campus Beilinson, Petah Tikva 49100, Israel.
Abstract
n-3 Fatty acids are recognised as influencing both wound healing and immunity.
We assessed the impact of a fish oil- and micronutrient-enriched formula (study
formula) on the healing of pressure ulcers and on immune function in critically
ill patients in an intensive care unit. A total of forty patients with pressure
ulcers and receiving nutritional support were enrolled (intervention group, n
20, received study formula; and a control group, n 20, received an isoenergetic
formula). Total and differential leucocyte count and percentage of adhesion
molecule positive granulocyte and lymphocyte cells (CD11a, CD11b, CD18 and
CD49b) were measured on days 0, 7 and 14. Percentage of positive lymphocytes
for CD54, CD49b, CD49d and CD8 were also measured on days 0, 7 and 14. The
state of pressure ulcers was assessed by using the pressure ulcer scale for
healing tool score on days 7, 14 and 28 of treatment. No between-group
differences in patient demographics, anthropometry or diagnostic class were
observed. Patients who received the study formula showed significant increases
in the percentage of positive CD18 and CD11a lymphocytes and of CD49b
granulocytes as compared to controls (P < 0?05). While the severity of pressure
ulcers was not significantly different between the two groups on admission,
severity increased significantly over time for the control group (P < 0?05),
but not for the study group. The present study suggests that a fish oil- and
micronutrient-enriched formula may prevent worsening of pressure ulcers and
that this effect may be mediated by an effect on adhesion molecule expression.

Source: Br J Nutr. 2011 Nov 1:1-6. [Epub ahead of print]

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