(09-01-12) Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight

Calcium and vitamin D supplementation is associated with decreased abdominal visceral adipose tissue in overweight and obese adults1,2,3,4

1. Jennifer L Rosenblum,
2. Victor M Castro,
3. Carolyn E Moore, and
4. Lee M Kaplan
+ Author Affiliations
1. 1From the Massachusetts General Hospital Weight Center and Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA (JLR, VMC, and LMK), and the Beverage Institute for Health & Wellness of The Coca-Cola Company (CEM).
+ Author Notes
↵2 Supported by the National Institute of Diabetes and Digestive and Kidney Diseases (DK046200), Beverage Institute for Health & Wellness of The Coca-Cola Company, and the Massachusetts General Hospital Weight Center.
↵3 Current address: Harvard Medical School, Boston, MA (JLR); Partners Healthcare, Boston, MA (VMC); and Nutrition and Food Sciences, Texas Woman's University, Houston, TX (CEM).
↵4 Address correspondence to LM Kaplan, MGH Weight Center, 50 Staniford Street, 4th Floor, Boston, MA. E-mail: [email protected].
Abstract
Background: Several studies suggest that calcium and vitamin D (CaD) may play a role in the regulation of abdominal fat mass.
Objective: This study investigated the effect of CaD-supplemented orange juice (OJ) on weight loss and reduction of visceral adipose tissue (VAT) in overweight and obese adults (mean ?? SD age: 40.0 ?? 12.9 y).
Design: Two parallel, double-blind, placebo-controlled trials were conducted with either regular or reduced-energy (lite) orange juice. For each 16-wk trial, 171 participants were randomly assigned to 1 of 2 groups. The treatment groups consumed three 240-mL glasses of OJ (regular or lite) fortified with 350 mg Ca and 100 IU vitamin D per serving, and the control groups consumed either unfortified regular or lite OJ. Computed tomography scans of VAT and subcutaneous adipose tissue were performed by imaging a single cut at the lumbar 4 level.
Results: After 16 wk, the average weight loss (??2.45 kg) did not differ significantly between groups. In the regular OJ trial, the reduction of VAT was significantly greater (P = 0.024) in the CaD group (−12.7 ?? 25.0 cm2) than in the control group (−1.3 ?? 13.6 cm2). In the lite OJ trial, the reduction of VAT was significantly greater (P = 0.039) in the CaD group (−13.1 ?? 18.4 cm2) than in the control group (−6.4 ?? 17.5 cm2) after control for baseline VAT. The effect of calcium and vitamin D on VAT remained highly significant when the results of the 2 trials were combined (P = 0.007).
Conclusions: The findings suggest that calcium and/or vitamin D supplementation contributes to a beneficial reduction of VAT. This trial is registered at clinicaltrial.gov as NCT00386672, NCT01363115.

Source: Am J Clin Nutr January 2012 vol. 95 no. 1 101-108

News

---

In evidenza

"L'informazione presente nel sito serve a migliorare, e non a sostituire, il rapporto medico-paziente."

Per coloro che hanno problemi di salute si consiglia di consultare sempre il proprio medico curante.