(10-01-2012) Isoflavone intake and risk of gastric cancer: a population-based prospective cohort study in Japan

1. Azusa Hara,
2. Shizuka Sasazuki,
3. Manami Inoue,
4. Motoki Iwasaki,
5. Taichi Shimazu,
6. Norie Sawada,
7. Taiki Yamaji,
8. Shoichiro Tsugane, and
9. for the Japan Public Health Center?Based Prospective Study Group
+ Author Affiliations
1. 1From the Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan.
+ Author Notes
↵2 Supported by Management Expenses Grants from the Government to the National Cancer Center, Grants-in-Aid for Cancer Research, and the Third Term Comprehensive 10-Year Strategy for Cancer Control (H21-Sanjigan-Ippan-003) from the Ministry of Health, Labor, and Welfare of Japan. AH received a research resident fellowship from the Foundation for Promotion of Cancer Research (Japan) for the third term Comprehensive 10-year Strategy for Cancer Control.
↵3 Address reprint requests and correspondence to S Sasazuki, Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. E-mail: [email protected].
Abstract
Background: Isoflavones are structurally similar to 17?-estradiol and may be able to prevent gastric cancer. However, there is contradictory evidence concerning the relation between the intake of soy food, which is rich in isoflavones, and gastric cancer. The association with gastric cancer might differ between isoflavones and soy foods, and research on the effects of isoflavone intake alone on gastric cancer is needed.
Objective: We investigated the association between isoflavone intake and the incidence of gastric cancer.
Design: We conducted a large, population-based prospective study of 39,569 men and 45,312 women aged 45?74 y. Dietary soy and isoflavone intakes were measured by using a validated food-frequency questionnaire in 1995 and 1998.
Results: During 806,550 person-years of follow-up, we identified 1249 new gastric cancer cases. Isoflavone intake was not associated with gastric cancer in either men or women. Compared with the lowest quartile, the HR and 95% CI for developing gastric cancer in the fourth quartile of isoflavone intake was 1.00 (0.81, 1.24) for men and 1.07 (0.77, 1.50) for women. In a stratified analysis by exogenous female hormones (women only), however, we found an increasing trend in risk of gastric cancer associated with higher isoflavone intakes among exogenous female hormone users (P-trend = 0.03) but not for nonusers (P-interaction = 0.04).
Conclusion: The current study does not support the hypothesis that higher intakes of isoflavones prevent gastric cancer in either men or women.

Source: Am J Clin Nutr January 2012 vol. 95 no. 1 147-154

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